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Thus, the association of Shank3 with mitochondrial proteins and processes, including the mitochondrial ETC activity, has been established, although the mechanisms connecting SHANKs and mitochondria at the excitatory synapses remain unknown

Conserved sequence and structural features include the SECIS core nucleotides (A/GUGA and GA), the stem length, and conserved adenosines in a terminal loop (marked as adenosine loop)

However, neither Erastin nor QCT has an effect on the ratio of phosphorylated ERK (pERK) to ERK (Fig