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Its expression is markedly reduced in both IBD patients and mouse models, correlating with reduced mitochondrial mass, elevated mtROS and impaired energy production [282, 283]

Clinical manifestation and long-term outcome of citrin deficiency: report from a nationwide study in Japan

From 15,046 genes, seven DEGs (Supplementary Data 4) were found with four significantly upregulated and three significantly downregulated in the SalA-treated group relative to the control A42-expressing Drosophila