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Preclinical studies (in vitro and animal) reveal mechanistic benefits such as gut microbiota modulation, improved barrier function, and metabolic regulation

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Furthermore, the regulatory effects of TCM on mTOR-related pathways in the context of DKD warrant further exploration and investigation

Adipose-specific Rictor knockout mice exhibit increased lean mass, likely due to elevated hepatic IGF-1 and pancreatic insulin secretion, as mTORC2 in white adipose tissue negatively regulates these hormones via feedback loops