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Global-scale profiling of differential expressed lysine-lactylated proteins in the cerebral endothelium of cerebral ischemiareperfusion injury rats

Pedersen HK, Gudmundsdottir V, Nielsen HB, Hyotylainen T, Nielsen T, Jensen BA, Forslund K, Hildebrand F, Prifti E, Falony G, Le Chatelier E, Levenez F, Dor J, Mattila I, Plichta DR, Ph P, Hellgren LI, Arumugam M, Sunagawa S, Vieira-Silva S, Jrgensen T, Holm JB, Trot K, MetaHIT C, Kristiansen K, Brix S, Raes J, Wang J, Hansen T, Bork P, Brunak S, Oresic M, Ehrlich SD, Pedersen O

5-Amino-1MQ Animal Studies Studies using 5-Amino-1MQ specifically have demonstrated its potency and selectivity as an NNMT inhibitor, with IC50 values in the low micromolar range and good selectivity over other methyltransferases

The research protocol was approved, and mice were maintained in accordance with institutional guidelines of the Fox Chase Cancer Center Animal Care and Use Committee