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4 Strengths and limitations This review integrates evidence across cellular, organ, and physiological levels, highlighting autophagy pathways, hormonal regulation involving GH, cortisol, insulin, leptin, and thyroid hormones, as well as cardiovascular, neurological, and gastrointestinal outcomes

This receptor profile has unique physiological effects, such as a noticeable decrease in stomach motility and brainstem-mediated signals of fullness

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Systemic inflammation has been linked to impaired cognitive function and aberrations in brain structure in many settings (refer to the Age-Related Cognitive Decline protocol for a more thorough discussion of the role of inflammation in cognitive dysfunction)