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an anthracycline such as aclarubicin, daunorubicin, doxorubicin, epirubicin, idarubicin, amrubicin, pirarubicin, valrubicin, or zorubicin an anthracenedione such as mitoxantrone, or pixantrone an anti-tumor antibiotic isolated from Streptomyces such as actinomycin the therapeutic agents may be formulated and/or administered with additional active agents such as one or more biological agents

Although several candidate drug resistance mechanisms, including impaired DNA repair, decreased drug uptake, increased drug efflux and detoxification, have been proposed (reviewed by Galluzzi et al, 2012), we are still some way from understanding the molecular basis of drug resistance, and from developing biomarkers to predict the onset and monitor the development of drug-resistant disease in cancer patients

Arachidonic acid is an omega-6 oil found mainly in animal foods, but the body can also create it from linoleic acid (corn oil, soybean oil)

Zhang, Y., Gaetano, C