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Hoppe Seylers Z Physiol Chem 365:195212

293,294 YAP can inhibit glucose-6-phosphatase catalytic subunit (G6PC) and phosphoenolpyruvate carboxykinase 1 (PCK1) via peroxisome proliferator-activated receptor gamma coactivator 1 (PGC-1), eventually hampering gluconeogenesis

Therefore, glutamine availability has a huge influence on pathogen and cancer defense ( Besides T cells, tumor tissues are often highly infiltrated by myeloid cells, especially so-called tumor-associated macrophages ( Up to now, glutamine metabolism and especially the influence of glutamine-deprivation on dendritic cell (DC) activation and differentiation is poorly explored