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Description

Mechanistically, circECE1 and c-Myc interact to hinder POZ-mediated degradation of ubiquitinated c-Myc

Candida glabrata peroxiredoxins, Tsa1 and Tsa2, and sulfiredoxin, Srx1, protect against oxidative damage and are necessary for virulence

doi: 10.1038/nature03128

JHU083 has also demonstrated excellent therapeutic efficacy in preclinical models of IDH-mutant gliomas and significantly reduces mTOR signaling (Yamashita et al., 2021)