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Without a systematic concept and detailed molecular knowledge, ferroptosis was attributed to the other existing forms of cell death and was considered to have no biological significance

Ethics statement All experimental procedures were approved by the Ethical Committee of the Faculty of Veterinary Medicine of the University of Ghent, Belgium (approval number EC2011-113), and carried out in accordance with the approved guidelines and regulations

A pharmacokinetic (PK) study confirmed L2-Cmu levels after a single injection were ~5-fold greater than the reported IC 90 values for Ganitumab (28 g/mL) in both sexes for at least 7 days (Supplementary Fig