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Disrupted ROS additionally impairs granulosa and theca cell activity, altering steroid hormone production and resulting in erratic cycles

In a rodent study, blocking DSIP activity reduced the increase in GH usually seen after sleep deprivation

Furthermore, death-domain associated protein 6 (DAXX) regulates Fas protein-dependent apoptotic signaling during myocardial ischemiareperfusion injury [465]

This section provides a comprehensive analysis of these side effects, their incidence rates, underlying mechanisms, 2025 research updates, long-term risk assessments, practical management strategies, considerations for special populations, safety protocols, and guidance on identifying suitable candidates