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Research suggests that factors like stress levels, muscle relaxation, and hydration may play a role in how the body responds to a shot

10.1038/s41586-020-2777-8 Nature 8 Baecher-AllanC.KaskowB

Depleting the dopamine level in PD will lead to overactivity of the indirect pathway and under activity of the direct pathway within the basal ganglia circuitry (41)