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The major hallmarks, as described by Pavlova and Thompson (7), include: deregulated glucose and amino acid uptake, opportunistic ways of acquiring nutrients, use of metabolic intermediates for biomass and nicotinamide adenine dinucleotide phosphate (NADPH) synthesis, increased demand for nitrogen, and alterations in metabolite-driven gene expression and interaction with the microenvironment (7, 9)

Aspartate and asparagine metabolism Aspartate can be generated from the TCA intermediate oxaloacetate by glutamate-mediated transaminase activity (Figure 2)

Aging is associated with a shift toward more pro-inflammatory oxylipin species, which may impair microvascular perfusion and attenuate anabolic responsiveness (96)