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Recently, interest in endophytic fungi and bacteria has grown because of the many benefits they provide to the host plant while reducing the use of chemicals in agriculture that benefit the environment and human health

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This landscape continues to pose a challenge for therapeutic efficacy

As an alternative chemotherapeutic agent, AMPs/ACPs display several extraordinary properties such as broad spectrum activity, high specificity, rapid mode of action, efficient tumor penetration due to small size, good solubility, low toxicity, ability to bypass the multidrug-resistance mechanism induced by tumor cells against conventional chemotherapy drugs and finally capability to produce in commercially available scale and make AMPs/ACPs as suitable candidates for the development of novel anticancer agents