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In HCC33 and H82, in which TXNRD1 inhibition induced high levels of hydrogen peroxide (H 2 O 2 ) and hydroxyl radical (OH), the iron/copper chelator deferoxamine (DFO) strongly reduces cell death, presumably by preventing the formation of toxic levels of OH

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It is important to note that liposuction and other surgical interventions are not definitive cures for lipedema, as patients typically require ongoing maintenance of conservative treatment pillars throughout their lives