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To provide an assessment of fidelity of intervention delivery, 20% of the recorded sessions will be reviewed and rated according to a fidelity checklist by the independent observers

Based on the phase 2 and phase 3 trial protocols: Weeks 1-4: 1 mg once weekly Weeks 5-8: 2 mg once weekly Weeks 9-12: 4 mg once weekly Weeks 13-16: 8 mg once weekly Weeks 17 onward: 12 mg once weekly (maximum dose) The starting dose of retatrutide is deliberately low because the triple-agonist mechanism produces more intense initial side effects than single-pathway compounds

Immune Support: Vitamin A is essential for a well-functioning immune system

Some research has found that people with obesity had lower levels of vitamin B-12, but further studies are needed to confirm a link between weight and B12 levels