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Next, the differential abundance analysis was repeated for the entire cohort of PD patients, i.e., comparing 549 patients against 590 controls, using the same statistical approach but including the abundance measurements for the L-DOPA metabolite 3-O-Methyldopa (3-OMD, 3-methoxytyrosine) as an additional covariate to adjust for dopaminergic treatment effects (L-DOPA itself was not covered among the measured metabolites, see section on Study limitations)

doi: 10.1183/09031936.00029011 226 FisherSARahimzadehMBrierleyCGrationBDoreeCKimberCEet al

Conclusion Hospice care is a growing field in nursing and medicine in the United States and globally