glutathione in er lumen Thapsigargin and cyclosporine A increase levels the A Major Fraction of Endoplasmic

Sedlak TW, Paul BD, Parker GM, Hester LD, Snowman AM, Taniguchi Y, Kamiya A, Snyder SH, Sawa A

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human data are limited, and many mechanistic pathways are inferred from animal or in-vitro experiments

a reduction in both NAD+ levels and mitochondrial function is linked to accelerated aging and, likely, to graying hair