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doi: 10.1371/journal.pone.0043700 111 KotB

Nanobiosystems for Antimicrobial Drug-Resistant Infections

In addition, released cathepsin B can activates NLRP3 and caspase-1 by binding to the leucine-rich repeat domain of NLRP3, hinting to the critical involvement of lysosomal damage in cellular pyroptosis 11