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This stimulation could be abrogated by modulation of Glo-I activity by means of EP (Figure 2c)

coli residing inside tumors compromises the gut vascular barrier, a structural element regulating bacterial distribution along the gut-liver axis, influenced by the virulence regulator

Representative strategies targeting this axis, from glycolytic enzyme inhibitors to lactylation modulators, have advanced from preclinical validation to early-phase clinical trials, with select agents demonstrated preliminary safety and target engagement