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Oxidative stress and new pathogenetic mechanisms in endothelial dysfunction: potential diagnostic biomarkers and therapeutic targets

In the past, necrotic tubules were considered to be apoptosis because of positivity of terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) staining, which detects DNA double-strand breaks that occur during apoptosis [28] However, TUNEL staining, once considered an indicative of apoptosis, is now recognized to also mark other forms of regulated cell death, including ferroptosis [28]

& Cosentino Lagomarsino, M

Wall et al, 1980), homocysteine alters endothelium antithrombotic properties (Harpel et al, 1996)