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9 Toxicology and side effects Current evidence reveals an intrinsic paradox between therapeutic efficacy and safety profiles of bioactive compounds - no identified pharmacologically active agent completely avoids non-specific off-target effects on healthy tissues ( in vitro study demonstrated that shikonin has potent cytotoxicity against 15 types of cancer cells through mitochondrial dysfunction and can induce apoptosis

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Bhatia et al., 2012)