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Supplementation is needed to raise plasma CoQ10 concentrations to the 2.5 micrograms per milliliter level necessary for adjuvant therapeutic use for heart disease (Langsjoen 2014) and to the level of 3.5 micrograms per milliliter needed in the treatment of neurodegenerative diseases (Langsjoen 2014)

Paradoxically, CoQ 10 also exhibits pro-oxidant activity that occurs either due to a CoQ 10 semiquinone reaction 5 or due to a reaction with oxygen when CoQ 10 is in its oxidized state 7