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Conversely, NRF2 activators like SFN, RSV, and curcumin enhance NRF2-mediated antioxidant defenses, offering cytoprotection in degenerative and inflammatory conditions

Concurrently, LPS significantly elevated TNF- and IL-6 levels in BALF, which were markedly decreased in mice pretreated with 10 g/g GHK-Cu

The relative GPX4 deficiency will perturb mitophagy and, subsequently, results in failure of reticulocyte maturation, which can be defined as late stage ineffective erythropoiesis

These epoxide hydroxylases can bind to and inhibit anti-inflammatory arachidonic acid derivatives, thereby promoting inflammation (Ghosh et al., 2020