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Combination of linsitinib and the ER antagonist fulvestrant is more effective to inhibit hormone-independent breast cancer growth than the single agent [108]

Since a number of kinases such as protein kinase N (PKN) and the mitogen-activated protein kinase (MAPK) p38 are known to be sensitive to cellular stress conditions, such as changes in osmolarity, it is also conceivable how stress-induced signal cascades could lead to alterations in the uptake of specific proteins by introducing the phosphorylation of cargo or adaptor proteins

Safety aspects of genetically modified lactic acid bacteria

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