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Exp Gerontol 43(7):615622 Asaro A, Carlo-Spiewok AS, Malik AR, Rothe M, Schipke CG, Peters O, Heeren J, Willnow TE (2020) Apolipoprotein E4 disrupts the neuroprotective action of sortilin in neuronal lipid metabolism and endocannabinoid signaling

These actions involve upregulation of TIMP-1 (tissue inhibitor of metalloproteinase) and MMP-2 (matrix metalloproteinase), both key factors in tumor metastasis (517)