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Despite the potential of these novel therapies, the article acknowledges several limitations, including the variability in patient responses and the challenges of long-term adherence to treatment regimens

When used together, MTX and the added drugs can attack joint inflammation from multiple, complementary angles, producing a synergistic effect that is more powerful than either drug alone (Friedman & Cronstein, 2019)

A 2018 study highlighted this importance

Factors like stress, aging, digestive conditions, and Northern Michigan's long winters can deplete essential nutrients faster than your body can replenish them