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doi:10.1093/clinchem/30.6.884

Thus, radiation-induced Drp1-mediated mitochondrial fission serves as a critical pro-survival mechanism that inhibits apoptosis, promotes mitophagy and metabolic reprogramming, and drives radioresistance, whereas blocking fission shifts the balance toward mitochondrial elongation, cell cycle arrest, and enhanced radiation sensitivity -underscoring Drp1 as a compelling therapeutic target to overcome radioresistance