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Screening by determining total homocysteine (tHcy) in dried blood spots is only occasionally performed given the need for a reduction step prior to LC-MS/MS assay and associated costs [42]

These findings are supported by mechanistic investigations that have identified multiple pathways through which environmental toxicants can induce DNA fragmentation in spermatozoa, including oxidative stress, mitochondrial dysfunction, and direct genotoxic effects (67)

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424 In AD, GLP-1(7-36) amide inhibits IL-1 transcription and prevents cognitive dysfunction, amyloid precursor protein synthesis, and cell death