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This competitive interaction has important therapeutic implications, as Fe supplementation is used to treat Mn-related metabolic disorders, possibly by reducing oxidative damage 115

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As this research moves forward, we suggest that metabolites could be delivered for clinical use via at least three distinct routes: i) clinical grade nutrients could be prepared by an independent process and then used with antibiotic drugs

G., Hard and Soft Acids and Bases , Dowen, Hutchinson and Ross, Stroudsberg, 1973