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Additionally, in mice with experimental tubulointerstitial nephritis, renoprotection was observed in conjunction with a reduction in the expression of inflammatory molecules when allopurinol or the blockade of genes linked to the NLRP3 inflammasome response (apoptosis-associated speck-like protein containing C-terminal caspase recruitment domain [CARD] (ASC) and caspase 1) was administered (126)

Magos, L., & Clarkson, T

Although the rejection decreased and the mice gained weight by 8 weeks after transplantation, a mild immune cell infiltrate persisted and fibrosis was observed even 64 weeks after transplantation

Kharman-Biz A, Gao H, Ghiasvand R, Zhao C, Zendehdel K, Dahlman-Wright K (2013) Expression of activator protein-1 (AP-1) family members in breast cancer