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Downregulation of Endogenous Peptide Production Introducing exogenous peptides may signal the body to decrease its own production of these compounds (a concept well-understood with hormonal therapies)

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Targeted PubMed searches yielded 8 high-quality peer-reviewed references meeting criteria, falling short of the 12-reference threshold

Epitalon has been shown to increase IL-2 mRNA expression in both human in vitro and animal in vivo studies, but its effects appear especially pronounced in aged tissues [4, 48], pointing toward a role in immunorejuvenation rather than broad immunostimulation