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For the hepsin / mice, the timing of mortality was such that it occurred prior the onset of liver repair and regeneration processes, thereby confirming the role of hepsin in determining the mechanism of APAP toxicity tolerance during the early phase of drug exposure

[1] [2] This combined approach results in improved glycemic control, significant weight reduction, and improvements in certain cardiovascular risk factors such as blood pressure and lipid profiles

doi: 10.1111/1753-0407.70069 157 TimmonsJBoyleJ