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doi: 10.1007/s12035-011-8181-5

Gene Therapy for Parkinsons Disease Associated with GBA1 Mutations

ROS-dependent generation of lipid peroxidation products results in an increase in the level of small-molecule, unsaturated, reactive aldehydes (e.g., 4-hydroxy-2-nonenal (4-HNE) and malondialdehyde (MDA)) and cyclization products, including iso- and neuroprostanes 9 , while the enzymatic hydrolysis of phospholipids promotes the increase in the level of endocannabinoids (with the participation of phospholipases and diacylglycerol (DAGL)) and free polyunsaturated fatty acids (PUFAs) (with the involvement of phospholipases A (PLAs))

Since the 1990s, folate status and genetics have been linked to a plethora of diseases, many of which stem from impaired DNA-thymidylate and methylation pathways, and include adverse prenatal, oncogenic, cardiovascular and neurological outcomes