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Inclusion Criteria Exclusion Criteria Timeline for a Trial Participant Screening Participants are screened for eligibility to participate in the trial Treatment Participants receive once-weekly subcutaneous injections of CagriSema or placebo for up to 40 weeks, with dose escalation periods for active comparators Follow-up Participants are monitored for safety and effectiveness after treatment What Are the Treatments Tested in This Trial

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Taken together, the above results support the notion that neutrophilic granules are transferred intercellularly into tumor cells, and it is the neutrophilic granular contents, such as MPO as demonstrated here, which induce ferroptosis in tumor cells