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Subsequent studies by Fritz and Yue (1963) led to a conceptual framework depicting how carnitine enables long-chain FA esterification to CoA in the extramitochondrial compartment to generate enzymes of -oxidation in the mitochondrial matrix, thus circumventing the permeability issue of the inner membrane to acyl-CoA esters

While these studies are valuable in elucidating the molecular mechanisms involved, clinical trials participating large cohorts are necessary to truly evaluate the effectiveness of polyphenol supplementation for human health

Similarly, there is a possibility of increased bleeding risks when taking anticoagulants

While early stages of HCC can often be treated with curative therapies or locoregional therapies, more than half of all patients with HCC develop advanced stage HCC and are eligible for systemic therapy