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If the vial was exposed to moisture before you opened it, the powder may have partially degraded

near the start, the protease may strip it Glutamine at any position contributes more than its share because P1 Q is the most stringent feature recognized Crystal structure: The TEV S1 pocket is deep and Gln-specific (Phan et al., 2002), but the S2S6 pockets are shallow and water-mediated, explaining the tolerance (Phan et al., 2002)