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Blood (2017) 130:510

Yonsei Med J 52(2):326332 Li M, Xu S, Geng Y, Sun L, Wang R, Yan Y, Wang H, Li Y, Yi Q, Zhang Y, Hao J, Deng C, Li W, Xue L (2019) The protective effects of L-carnitine on myocardial ischemiareperfusion injury in patients with rheumatic valvular heart disease undergoing CPB surgery are associated with the suppression of NF-B pathway and the activation of Nrf2 pathway

However, overdose of APAP saturate the conjugation pathways and NAPQI overwhelms the GSH detoxifi-cation mechanism , finally leading to liver necrosis and may be death