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10.1111/j.1432-1033.2004.04067.x 92 SharmaR.SharmaA.ChaudharyP.PearceV.VatsyayanR.SinghS

The same authors also showed that the rectal administration of 300 mg/day melatonin to 31 sALS patients was well tolerated during an observation period of up to 2 years, reducing circulating serum protein carbonyls, however, without showing any evidences of upregulation of genes encoding antioxidant enzymes [54]