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Studies in which sleep deprivation (one or few nights) was applied to healthy humans during (mostly after) the immunological challenge of vaccination demonstrate that sleep deprivation reduced both the memory and effector phases of the immune response, as indexed by suppressed antigen-specific antibody and Th cell response compared with undisturbed sleep 117

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We demonstrate that IPA activates peroxisome proliferator-activated receptor alpha (PPAR) through specific ligand-binding domain interactions (Tyr314/Ile317), driving 3-hydroxy-3-methylglutaryl-CoA synthetase 2 (HMGCS2)-mediated ketogenesis to elevate -hydroxybutyrate (BHB) production