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SES-CD was assessed during colonoscopy or single-balloon enteroscopy by the endoscopist based on the size of mucosal ulcers, ulcerated surface, endoscopic extension and the presence of stenosis in the ileum, right colon, transverse colon, left colon and rectum regardless of previous bowel resection

Conversely, cartilage-specific overexpression of GPX4 via transgenic technology, or restoration of its activity using small molecule drugs such as certain natural compounds or ferroptosis inhibitors, can significantly delay cartilage degeneration, improve subchondral bone sclerosis and osteophyte formation, and alleviate synovitis in model animals (Xiao et al., 2024), which directly confirms the protective role of GPX4 in OA progression from a gain-of-function perspective

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