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Dysfunction in mitochondria can lead to electron leakage in the electron transport chain, resulting in overproduction of ROS such as superoxide anions and hydrogen peroxide ( Endoplasmic reticulum oxidative stress: The endoplasmic reticulum (ER), responsible for protein synthesis and folding, is vulnerable to oxidative stress

doi: 10.1016/j.plaphy.2012.03.016 26

Metabolic response in the late 72 h reperfusion time suggests that neural cells accelerate glutamate metabolic recovery to substitute the deprivation induced by ischemic event and presumably compensate for the altered synthetic function of damaged neural cells