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Advanced Care Research Centre at the University of Edinburgh

Geographically, Latin America and the Caribbean had the highest proportion of DR-related blindness (6.9%), whereas North Africa and the Middle East reported the highest rates of MSVI (2.1%)

170 By contrast, in older humans and in the mature rhesus monkey and other mammals beyond the newborn period, hepatic excretion of conjugated bilirubin into bile predominates as the rate-limiting step in the presence of a large bilirubin load

Pharmacokinetics & drug-delivery barriers Many ferroptosis inhibitors are lipophilic small molecules that suffer from rapid metabolism and clearance, yielding subtherapeutic bioavailability in cardiac tissue