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ArticlePubMedPMC 21

Importantly, the accumulation of iron and ROS within BM CD34 + cells may contribute to genetic and chromosomal abnormalities, which, in turn, accelerate blast proliferation and prompt MDS transformation into AML [192]

In turn, iron is also required for the normal growth and proliferation of microorganisms, but excess iron leads to the overgrowth of harmful bacteria such as Escherichia coli ( E