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Many dietary antioxidants can reduce oxidative stress injury in vitro , whereas in vivo the non permeability of the BBB is considered one of the greatest challenges, which makes it particularly difficult for antioxidant compounds to enter the brain tissue

Compound 102 passed the PAINS (pan assay interference compounds) remover, which filters out compounds that appear as frequent hitters (promiscuous compounds) in many biochemical high throughput screens

TP0473292 is an adamantane carboxylic acid ester prodrug, which can be used as a novel antidepressant that enhances metabotropic glutamate 2/3 receptor antagonist oral bioavailability

Li Y, Yang W, Tang Y, Du S, Ye Y, Xu B, et al