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For suspected macro-B12, precipitation with PEG is the test most often reached for, though it is nonspecific and can remove B12 that is fully available to cells, so direct measurement of the binding proteins, haptocorrin and transcobalamin, may be more informative when it is available

As SOD2 is induced by hypoxia and subsequent HIF-1 activation, it is highly upregulated after wounding 52,53