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However, leukemia cells take advantage of iron overload to fuel their rapid proliferations by relying on iron-dependent ribonucleotide reductase, an enzyme required for DNA synthesis (132134)

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Sumihito Togi, Misa Togi, Satoshi Nagashima, Yuichi Kitai, Ryuta Muromoto, Jun-ichi Kashiwakura, Toshiaki Miura, Tadashi Matsuda, Implication of NF-B Activation on Ozone-Induced HO-1 Activation, BPB Reports, 2021, Volume 4, Issue 2, 14

By monitoring the conversion of hyperpolarized [1- 13 C]pyruvate to [1- 13 C]lactate and [ 13 C]bicarbonate, researchers have quantified the rates of LDH and PDH enzymes