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Antisense oligonucleotides: a primer

These findings suggest that DHA can enter lipid droplets, interact with heme or hemozoin, and interfere with heme crystallization (i.e., hemozoin formation)

However, a significant challenge is the non-specificity of broad-spectrum HDAC inhibitors, which can lead to off-target effects and side effects by affecting acetylation states in numerous cell types and tissues beyond the auditory pathway, limiting their clinical utility for a condition like tinnitus

It has to be critically mentioned that exclusively the protein binding of unconjugated polyphenols was determined in that study since conjugated reference compounds were not available