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While preclinical research and anecdotal reports are promising, human studies are extremely limited, and safety profiles remain uncertain

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nepjol.infoD Malla, Bajracharya MR, Karki BB, Rajouria AD (2021) PS ShresthaJournal of Diabetes and Endocrinology Association of Nepal, 2021nepjol.info 5:3943 Yadav A, Jyoti S, Mehta RK, Parajuli SB Vitamin B12 deficiency among metformin treated type 2 diabetic mellitus patients visiting the Department of Medicine of a tertiary care centre., Yadav S, Jyoti RK, Mehta (2023) SB ParajuliJNMA: Journal of the Nepal Medical Association, 2023pmc.ncbi.nlm.nih.gov 61:861863 Gao L, Ran X, Liu X, Shen X, Chen S, FL-J of (2023) undefined The effects of daily dose and treatment duration of metformin on the prevalence of vitamin B12 deficiency and peripheral neuropathy in Chinese patients with type 2