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These distinct mechanisms may include systemic dysfunction-induced neurologic injury, renin-angiotensin system (RAS) dysfunction, immune dysfunction, and direct viral invasion of the nervous system, as elaborated and summarized in Table 1 [55,56,57,58,59,60,61,62,63,64,65,66,67,68,69,70,71] and Fig

239 Elevated expression of ATG genes, including ATG4B, ATG4D, ATG5, and BECN1, underscores its mechanistic relevance, 240 and ATG4B knockdown sensitizes cells to therapy

An ongoing phase II clinical trial is evaluating the effects of different doses of bimagrumab (up to 30 mg/kg) in combination with semaglutide for the treatment of obesity