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However, symptoms that worsen progressively, spread beyond the immediate injection area, or are accompanied by systemic symptoms such as fever or malaise warrant prompt medical evaluation

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What has human clinical evidence: ARA-290 produced measurable nerve fiber regrowth in humans with small fiber neuropathy in placebo-controlled trials over 28 days

Dosing concentrations designed for research titration , not calibrated for human pharmacokinetics a mismatch that has been linked in FDA adverse event reports to severe gastrointestinal illness and, in some cases, overdose from concentration errors